Impact of inter-pregnancy interval on long-term endo-metabolic health of the offspring

Seidman Liron, Wainstock Tamar, Sheiner Eyal, Pariente Gali, Sergienko Ruslan, Walfisch Asnat


Background: Inter-pregnancy interval (IPI), defined as the time interval between a live birth and estimated conception time of a subsequent pregnancy, has an established effect on perinatal outcome. The long-term impact of IPI on offspring is unknown. This study aimed to examine the effect of short and long IPIs on long-term endo-metabolic health of offspring.

Subjects and Method: This population-based cohort study included singleton live births in parturient with at least one previous birth. Singleton deliveries between the years 1991-2014 in a regional tertiary medical center were included. Offspring were followed until 18 years of age for endo-metabolic related hospitalizations. Survival curves were used to compare cumulative incidence of endo-metabolic morbidity, and Cox proportional hazards models to control for confounders.

Results: During the study period 144,397 deliveries met the inclusion criteria. Offspring following long IPIs exhibited higher rates of endo-metabolic related hospitalizations. Survival curve demonstrated a significantly higher cumulative incidence of endo-metabolic morbidity in the long IPI group (p<0.001). The Cox model demonstrated long IPI to significantly increase the risk for endo-metabolic related hospitalizations during childhood (aHR= 1.34, 95%CI= 1.06 to 1.70; p=0.015).

Conclusion: Long IPI appears to have an independent impact on long-term endo-metabolic health of the offspring.

Keywords: pregnancy interval, offspring, endocrine health, metabolic morbidity, obesity

Correspondence: Liron Seidman. The Goldman Medical School at the Faculty of Health Sciences, Ben-Gurion University of the Negev. Ben-Gurion University Medical School, Soroka University Medical Center, 151 IzakRager Ave, Be’er-Sheva 84101, Israel. Email: Mobile: +972-524215808

Journal of Maternal and Child Health (2020, 5(3): 321-330

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