The Effect of Asphyxia on Neonatal Death: A Meta-Analysis

Silvalia Rahma Pratiwi, Hanung Prasetya, Bhisma Murti


Background:  Asphyxia is the second leading cau­se of neonatal death in the world. The indi­ca­tor for the diagnosis of asphyxia in newborns is the APGAR (Appearance, Pulse, Grimace, Acti­vi­ty, and Respiration) score. APGAR score at the fifth minute of life correlated with the asphyxia deg­ree. This study aimed to estimate how great the effect of asphyxia on neonatal death based on the results of some previous studies.

Subjects and Method: This was a systematic and meta-analysis study. The articles used in this study were obtained from several databases in­clud­­­ing PubMed, Science Direct, and Google Scho­lar. The articles used in this study were ar­ticles that have been published from 2010-2020. The article was searched by considering the eli­gi­bi­l­ity criteria defined using the PICO model. The po­pulation of this study was neonatal with inter­ven­tion in the form of asphyxia, comparison, name­ly non-asphyxia, and outcome in the form of death. These articles were collected for 1 month. The keywords were "neonatal" AND "as­phy­­xia" OR "APGAR score" AND "mortality", "death neonatal asphyxia" OR "mortality as­phy­xia" AND "cross sectional". The articles included in this study were full-text articles with a cross-sectional study design. The articles were collected using PRISMA flow diagrams. The articles were ana­lyzed using the Review Manager 5.3 application.

Results: 6 articles were reviewed in this study. This study showed that asphyxia increas­­ed the risk of neonatal death (aOR= 3.52; 95% CI= 1.05 to 11.82; p=0.040).

Conclusion: Asphyxia increases the risk of neo­n­a­tal death.

Keywords: Asphyxia, APGAR score, neonatal mor­tality, neonatal death

Correspondence: Silvalia Rahma Pratiwi. Masters Program in Public Health, Univeritas Sebelas Maret. Jl. Ir. Su­ta­mi 36A, Surakarta 57126, Central Java. Email: sil­­

Journal of Maternal and Child Health (2020), 05(04): 413-421

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