Meta-Analysis the Effect of Obesity on Polycystic Ovary Syndrome and Anemia in Women of Reproductive Age

Nabila Aulia Tsaqifah, Rita Benya Adriani, Bhisma Murti


Background: Obesity in women of reproduc­tive age is a nutritional problem that needs attention because obesity affects other health problems, especially problems of nutri­ent absorption and reproductive health. This needs special attention considering that the health of women of reproductive age has a major influ­ence on the quality of future gene­rations. The purpose of this study was to esti­mate the mag­nitude of the effect of obesity on the possibility of polycystic ovary syndrome (PCOS) and anemia in women of reproductive age.

Subjects and Method: Systematic review and meta-analysis. The data of this study used a research research design obtained from the databases of Google Scholar, PubMed, BMJ, ScienceDirect, SpingerLink, and Sage. The inclusion criteria used were full paper, cross-sectional and cohort study designs with report­ed results adjusted odds ratio (aOR). Article searches were performed using the PICO model. Population= women of reproductive age, Intervention= Obesity, Compari­son= not obese, Outcome= anemia and PCOS. Articles were collected using PRISMA diagrams and analyzed using the Review Manager application (RevMan5.3).

Results: A total of 10 articles on the relation­ship of obesity with anemia and 4 articles on the relationship of obesity with PCOS. Studies show that obesity reduced the risk of anemia compared to normal weight in women of repro­ductive age (aOR= 0.73; 95% CI= 0.63 to 0.84; p<0.001). Obesity increased the risk of PCOS 1.21 times compared to women with normal weight (aOR= 1.21; 95% CI= 1.00 to 1.48; p= 0.050).

Conclusion: Obesity reduces the risk of anemia. Obesity increases the risk of PCOS in women of reproductive age.

Keywords: Obesity, anemia, PCOS, women of reproductive age.

Correspondence: Nabila Aulia Tsaqifah. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 085­607389109.

Journal of Maternal and Child Health (2021), 06(04): 409-422

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