Meta-Analysis the Effect of Combination Oral Contraceptive on the Risk of Venous Thromboembolism and Stroke in Family Planning Acceptors

Putri Yunita Sari, Eti Poncorini Pamungkasari, Bhisma Murti


Background: The global percentage of con­traceptive users in women of reproductive age range (15-49 years) or women who are married is 62.7%. Combined oral contraceptives repre­sent 8.8% of the prevalence (more than 100 million women). COCs are very effective in preventing pregnancy, but like most medi­ca­tions, combined oral contraceptives can be asso­ciated with a variety of side effects and risks, including venous thromboembolism (VTE) and stroke. This study aims to determine the estimated effect of combined oral contra­ceptives on venous thromboembolism and stroke on family planning acceptors by meta-analysis.

Subjects and Method: Meta-analyzes were performed by searching for articles from the Google Scholar, PubMed, Research Gate, Sco­pus, Springer Link, and Science direct data­bases. The keywords used in the search for the article included “oral contraceptive” OR “com­bined oral contraceptives” OR “risk factor” AND “venous thrombolism” OR “VTE” AND “stroke” AND “family planning”. The inclusion criteria in this study were full text articles, from 2000-2020, with a case-control study design. The article analysis was carried out using RevMan 5.3.

Results: There are 15 articles analyzed. The results showed that combined oral contra­ceptives increased the incidence of venous thromboembolism and stroke in family plan­ning acceptors (aOR 2.95; 95% CI = 1.80-4.84; p <0.001); (aOR 1.50; 95% CI = 1.30-1.74; p <0.001). The results of the meta-analysis showed a publication bias between the use of combined oral contraceptives and the incidence of stroke among family planning acceptors.

Conclusion: Combined oral contraceptives affect venous thromboembolism and stroke in family planning acceptors.

Keywords: COCs, venous thromboembolism, stroke, family planning acceptors

Correspondence: Putri Yunita Sari, Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 08818­794685.

Journal of Maternal and Child Health (2021), 06(02): 131-145

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