A Comparative Study of the Incidence of Hypoglycaemia and Hypocalcaemia in Neonatal Seizures Occurring within 72 Hours of Birth Admitted in NICU at a Tertiary Care Centre
DOI:
https://doi.org/10.26911/thejmch.2022.07.02.11Abstract
Background: Recognition of hypoglycaemia and hypocalcaemia in Neonatal seizures is important for to prompt diagnosis and therapeutic implications. Study aimed to analyse the incidence of hypoglycaemia and hypocalcaemia in neonatal seizures occurring within 72 hours of birth in 32-37 weeks preterm and term (37-42 weeks) babies.
Subjects and Method: A prospective hospital based observational study enrolled total of 105 neonates presenting with seizures activity within 72 hours of birth admitted to NICU of SV Medical College, Tirupati from September 2013 to October 2014. Samples selected by Simple random sampling method. Detailed antenatal, natal and postnatal history including CNS examination were taken and investigations estimated includes complete blood counts and picture, random blood sugar, and serum ionic calcium. The analysis data was chi square test with SPSS for Windows (Ver 20), SPSS Inc. New York.
Results: The results was In neonatal seizures occurring within 72 hours of birth, hypoglycaemia (62.9%) was common, more so in preterm babies both hypoglycaemia 9 (37.5%) and combination of hypoglycaemia and hypocalcaemia 9 (37.5%). The association between type of delivery and hypoglycaemia/ hypocalcaemia shown significant different (p=0.002). The association between Birth Weight and hypoglycaemia/ hypocalcaemia shown a very high significant different (p< 0.001).
Conclusion: In neonatal seizures occurring within 72 hours of birth, hypoglycaemia (62.9%) was common, more so in preterm babies both hypoglycaemia 09 (37.5%) and combination of hypoglycaemia and hypocalcaemia 09 (37.5%).
Keywords:
neonatal seizures, hypoglycaemia, hypocalcaemiaReferences
Sood A, Grover N (2003). Biochemical abnormalities in neonatal seizures. Indian J Pediatr. 70(3): 221-4. doi: 10.1007/BF02725588.
Brunquell PJ (2002). Prediction of outcome based on clinical seizures type in newborn infants. J Pediatr. 140(6): 707-12. doi: 10.1067/mpd.2002.1247-73.
Connell J, Oozeer R, De Vries L, Dubowitz LM, Dubowitz V (1989). Continuous EEG monitoring of neonatal seizures: diagnostic and prognostic considerations. Arch Dis Child. 64(4): 452-8. doi: 10.1136/adc.64.4_spec_no.452.
Connerty HV, Brigg AR (1966). Determination of serum calcium by means of ortho cresolphthalein complexone. Am J Clin Pathol. 45: 290-6. doi: 10.1093/ajcp/45.3.290.
Das D, Debbarma SK (2016). A study on clinico-biochemical profile of neonatal seizure. J Neurosci Res. 6(5-6): 95-101. doi: https://doi.org/10.14740-/jnr404w.
Kumar A, Gupta A, Talukdar B (2007). Clinico-etiological and EEG profile of neonatal seizures. Indian J Pediatr. 74(1):33-7. doi: 10.1007/s12098-007-0023-0.
Lakra M, Vilhekar KY, Chaturvedi (2003). Clinico-biochemical profile of neo-natal seizures in a rural medical college. In: Fernandez A, Dadhich JP, Saluja S, Editors, Abstracts, XXIII Annual Convention of National Neonatology Forum. Hyderabad. 121-122.
Lilien LD, Pildes RS, Srinivasan G, Voora S, Yeh TF (1980). Treatment of neonatal hypoglycemia with minibolus and intravenous glucose infusion. J Pediatr. 97(2): 295-8. doi: 10.1016/s0022-3476(80)80499-9.
Manoj D, Reddy RK, Prakash SS (2019). Biochemical abnormalities in neonatal seizures in term and preterm neonates. Int J Contemp Pediatr. 6: 40-5. doi: http://dx.doi.org/10.18203/234-9-3291.ijcp20184695.
McLean CW, Noori S, Cayabyab RG, Seri I (2012). Cerebral circulation and hypotension in the premature infant: diagnosis and treatment. Neurology. http://dx.doi.org/10.1016/B978-1-4377-3611-3.00002-X.
Mizrahi EM, Watanabe K (2005). Symptomatic neonatal seizures. In Epileptic syndromes in infancy, childhood and adolescence 2005: 17-38. John Libbey Eurotext, Montrouge, France.
Moayedi AR, Zakeri S (2007). Neonatal seizure: Etiology and type. J Child Neurology. 2:23-6. https://doi.org/1-0.22037/ijcn.v2i2.458.
Reddy KV, Soren C, Jagtap S, Pardhasa-radhi Y, Satish S (2018). Clinico-etiological profile of neonatal seizures in term neonates. Indian J Pediatr. 7(4): 211. https://nijp.org/clinico-etiological-profile-of-neonatal-seizures-in-term-neonates-2/.
Ronen GM, Penny S, Andrews W (1999). The epidemiology of clinical neonatal seizures in newfound land: A population-based study. J Pediatr. 134(1): 71-5. https://doi.org/10.1016/s0022-3476(99)70374-4.
Shah GS, Singh MK, Budhathoki S, Kalak-heti BK, Baral DD (2008). Clinico-biochemical profile of neonatal seizure. J Nepal Paediatr Soc. 28(1): 7-9. https://doi.org/10.3126/jnps.v2-8i1.1398.
Singhal PK, Singh M, Paul VK, Deorari AK, Ghorpade MG, Malhotra A (1992). Neonatal hypoglycemia-clinical profile and glucose requirements. Indian Pediatr. 29(2):167-71.
Tekgul H, Gauvreau K, Soul J, Murphy L, Robertson R, Stewart J, Volpe J, et al. (2006). The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics. 117(4):1270-80. doi: 10.15-42/peds.2005-1178.
Vasudevan C, Levene M (2013). Epidemiology and aetiology of neonatal seizures. Semin Fetal Neonatal Med. 18(4):185-91. doi: 10.1016/j.siny.201-3.05.008.
