Differences Levels of Sodium, Potassium, Calcium, and Magnesium Before and After Cisplatin Administration in Child with Osteosarcoma
Abstract
Background: Cisplatin is one of the most commonly used cytostatic chemotherapy agents, especially in patients with solid tumors such as osteosarcoma. The exact mechanism of whether and how cisplatin causes electrolyte disturbances is still unclear. This study aims to determine the differences in levels of sodium, potassium, calcium, and magnesium with the administration of cisplatin in children with osteosarcoma.
Subjects and Method: This was an analytical retrospective study using secondary data in the form of medical records. The sample size in this study was calculated by the single proportion for
References
Anand A, Sebastian N (2015). Incidence and spectrum of electrolyte disturbances in cisplatin based chemotherapy. IJRMS. 3(12): 3824
Arndt CAS, Rose PS, Folpe AL, Laack NN (2012). Common musculoskeletal tumors of childhood and adolescence. Mayo Clin. Proc. 87(5): 475
Barton CD, Pizer B, Jones C, Oni L, Pirmohamed M, Hawacutt DB (2018). Identifying cisplatininduced kidney damage in paediatric oncology patients. Pediatr Nephrol. 33(9): 1467
Berardi R, Tornilai M, Lenci E, Pecci F, Morgese F, Rinaldi S (2019). Electrolyte disorders in cancer patients: a systematic review. J. cancer metastatis treat. 5:79. Doi: 10.20517/23944722.2019.008.
Bowman BT (2017). Electrolyte Disorders Associated with Cancer. J. Onco. Nephrol. 1(1): 30
Dahlan S (2009). Besar sampel penelitian, Jakarta: Salemba Medika.
Durfee RA, Mohammed M, Luu HH (2016). Review of Osteosarcoma and Current Management. Rheumatol Ther. 221
Latcha S (2015). Electrolyte Disorders in Cancer Patients. J. Onco nephrol. 131
Liamis G, Filippatos TD, Elisaf MS (2016). Electrolyte disorders associated with the use of anticancer drugs. Eur. J. Pharmacol. 78
Liu W, Qdaisat A, Soliman PT, Ramondetta L, Lopez G, Narayanan S, Zhou S, et al. (2019). Hypomagnesemia and Survival in Patients with Ovarian Cancer Who Received Chemotherapy with Carboplatin. The Oncologist. 24(6): e312
Marcdante K, Kliegman RM (2014). Nelson essentials of pediatrics ebook. Elsevier Health Sciences.
Misaghi A, Goldin A, Awad M, Kulidjian AA (2018). Osteosarcoma: A comprehensive review. SICOTJ. Doi: 10.1051/sicotj/2017028.
Oronsky B, Caroen S, Oronsky A, Dobalian VE, Oronsky N, Lybeck M, Reid TR, Carter CA (2017). Electrolyte disorders with platinumbased chemotherapy: mechanisms, manifestations and management. Cancer Chemother. Pharmacol. 80(5): 895
Oun R, Rowan E (2017). Cisplatin induced arrhythmia; electrolyte imbalance or disturbance of the SA node?. Eur. J. Pharmacol. 811: 125
Rodriguez M (1989). Refractory Potassium Repletion due to CisplatinInduced Magnesium Depletion. Arch. Intern. Med. 149(11): 2592. Doi: 10.1001/archinte.1989.00390110136030.
Rosner MH, Dalkin AC (2014). Electrolyte Disorders Associated With Cancer. Adv Chronic Kidney Dis. 21(1): 7
Shimada A, Takeuchi H, Fukuda K, Suda K, Nakamura R, Wada N, Kawakubo H (2018). Hyponatremia in patients with esophageal cancer treated with chemotherapy including cisplatin. Esophagus. 15(4): 209
Shirali A (2016). Electrolyte and acidbase disorders in malignancy. OncoNephrology Curriculum; American Society of Nephrology: Washington.17
Sihombing TY, Windiastuti E, Gatot D (2016). Osteosarkoma pada Anak di RS. Dr Cipto Mangunkusumo Jakarta. Sari Pediatri. 11(3): 179. Doi: 10.14238/sp11.3.2009.17983.
Windiastuti E, Nency YM, Multasih S, Sudarmanto B, Ugrasena IDG (2018). Buku Ajar Hematologi Onkologi Anak. Jakarta: Badan Penerbit Ikatan Dokter Anak Indonesia.
