Meta-Analysis Effects of Antenatal Care Visit and Knowledge on the Adherence of Iron Tablet and Folic Acid Consumption
DOI:
https://doi.org/10.26911/thejmch.2023.08.05.01Abstract
Background: Adherence to iron tablet and folic acid (IFA) supplementation is the main strategy for the prevention and control of iron deficiency and neural tube defects in pregnant women and the unborn child. This study aims to estimate the relationships of antenatal care (ANC) visits and maternal knowledge on IFA supplementation adherence in pregnant women.
Subjects and Method: This study is a systematic review and meta-analysis using the PRISMA flow chart and the PICO model. Population: pregnant women. Intervention: conduct antenatal care visits and have knowledge of IFA Supplementation. Comparison: did not make antenatal care visits and had no knowledge of IFA Supplementation. Outcome: IFA consumption compliance. The databases used are PubMed, Google Scholar, and SpringerLink with keywords (“Antenatal Care” OR “IFA Supplementation” OR “Compliance”) AND “cross sectional”. There were 11 cross-sectional studies published in 2011-2023 that met the inclusion criteria. Analysis was performed with RevMan 5.3.
Results: A meta-analysis of 11 cross-sectional studies from Ethiopia and Uganda was performed, with sample size= 4,367. This study showed that pregnant women who had regular ANC visits (aOR=2.22; 95% CI= 1.52 to 3.24; p < 0.001) and had good knowledge (aOR=2.48; 95% CI= 2.02 to 3.03; p<0.001) were more likely to adhere to IFA supplementation. The funnel plot indicates publication bias (overestimate).
Conclusion: Pregnant women with regular ANC visits and good knowledge have the possibility to adhere with IFA supplementation.
Keywords: antenatal care, knowledge, adherence.
Correspondence: Siti Fatimah Aminah Nikita Putri Adhila. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java 57126, Indonesia. Email: putriadhila00@gmail.com Mobile: +6282186635526.
References
Afolabi BB, Babah OA, Akinajo OR, Adaramoye VO, Adeyemo TA, Balogun M,Thomas AB et al. (2022). Intravenous versus oral iron for iron deficiency anaemia in pregnant Nigerian women. BMC, 23(1): 1–15. DOI: 10.1186/s13063022066902.
Agegnehu G, Atenafu A, Dagne H, Dagnew B (2019) . Adherence to iron and folic acid supplement and its associated factors among antenatal care attendant mothers in lay Armachiho Health Centers. Int. J. Reprod. Med. 2019 (1–9). DOI: 10.1155/2019/5863737.
Aji AS, Yusrawati, Malik SG,Lipoeto NI (2020). Prevalence of anemia and factors associated with pregnant women in West Sumatra. J. Gizi dan Dietetik Indones., 7(3): 97-106. DOI: 10.21927/ijnd.2019.
Al-Dankali MM, Al-Shakliah ANA, Ali NMA, Aqlan OMSM, Abdullah MAA, Aljahmi AOM(2022). Anemia and the adequacy of prenatal care according to kessner/ institute of medicine index. J. of MAR Gynecology. 3(3): 1–22. https://medicalandresearch.com/assets/articles/documents/ DOCUMENT_20220707150828.pdf.
Aroke D, Kadia BM,Njim T (2020). Iron stores in pregnant women with sickle cell disease: a systematic review. BMC Pregnancy Childbirth. 20(1): 1–8. https://doi.org/10.1186/ s12884020033268.
Assefa H, Abebe SM,Sisay M (2019). Magnitude and factors associated with adherence to iron and folic acid supplementation among pregnant women in Aykel town, Northwest Ethiopia. BMC Pregnancy Childbirth. 19(1): 1–8. DOI: 10.1186/s1288401924224
Berhane A,Belachew T (2022). Effect of picture-based health education and counselling on knowledge and adherence to preconception iron-folic acid supplementation among women planning to be pregnant in Eastern Ethiopia: a randomized controlled trial. J. Nutr. Sci., 11: 1-11. DOI: 10.1017/jns.2022.51.
Demisse B, Temesgen H, Dessie B, Kassa GM (2021). Adherence status to iron with folic acid supplementation and associated factors among pregnant women receiving antenatal care at public health facilities in Northwest Ethiopia. SAGE Open Med., 9: 1-11. DOI: 10.1177/20503121211049934.
Demis A, Geda B, Alemayehu T, Abebe H (2019). Iron and folic acid supplementation adherence among pregnant women attending antenatal care in North Wollo Zone northern Ethiopia: Institution based cross-sectional study. BMC. 12(1): 1-7. DOI: 10.1186/s1310401941422
Desta M, Kassie B, Chanie H, Mulugeta H,Yirga T, Temesgen H, Leshargie CT et al. (2019) . Adherence of iron and folic acid supplementation and determinants among pregnant women in Ethiopia. Reprod. Health. 16(1): 1–14. DOI: 10.1186/s12978-019-0848-9.
Fekadu M., Lolemo K,Amanuel F(2022). Factors associated with utilization of iron with folic acid supplement among pregnant women attending antenatal care at government health facilities and family guidance clinic in Hawassa City administration, Hawassa, Ethiopia. Clin. J. Obstet. Gynecol.5(2): 55–60. DOI: 10.29328/journal.cjog.1001108.
Fite MB, Assefa N,Mengiste B (2021). Prevalence and determinants of anemia among pregnant women in sub-Saharan Africa: a systematic review and meta-analysis. Arch. Public Health. 79(1): 1–11. DOI: 10.1186/s13690-021-00711-3.
Gebremariam AD, Tiruneh SA, Abate BA, Engidaw MT, Asnakew DT (2019). Adherence to iron with folic acid supplementation and its associated factors among pregnant women attending antenatal care follow up at Debre Tabor General Hospital, Ethiopia, 2017. BMC, 14(1):1-10. DOI: 10.1371/journal.pone.0210086.
Gebremichael TG,Welesamuel TG(2020). Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa Town, Tigray, Ethiopia: cross-sectional study. PLoS ONE. 15(1): 1–11. DOI: 10.1371/journal.pone.0227090
Gomaa E,Mohamed R (2020). Assessing adherence of pregnant women to iron supplementations in Sohag district. EJCM. 38(3): 19–29. DOI: 10.21608/ejcm.2020.105488.
Kadir NA, Rahim NAA, Mangantig E, Lah NAZK,Ahmad AH (2021) Knowledge of oral iron consumption among pregnant women at hospital universiti sains Malaysia. MJMHS. 17(9): 107–117. https://medic.upm.edu.my/upload/dokumen/ 2021112322455315_MJMHS_0896.pdf.
Kassa ZY, Awraris T, Daba AK,Tenaw Z(2019). Compliance with iron folic acid and associated factors among pregnant women through pill count in Hawassa city, South Ethiopia: A community based cross-sectional study. Reprod. Health. 16(1):10–17. DOI: 10.1186/s1297801906798.
Kiwanuka TS, Ononge S, Kiondo P, Namusoke F (2017). Adherence to iron supplements among women receiving antenatal care at Mulago National Referral Hospital, Uganda-cross-sectional study. BMC, 10(1): 1-6. DOI: 10.1186/s131040172834z.
Molla T, Guadu T, Muhammad EA, Hunegnaw MT (2019). Factors associated with adherence to iron folate supplementation among pregnant women in West Dembia district, Northwest Ethiopia: a cross sectional study. BMC Research Notes, 12(1): 1-6. DOI: 10.1186/s1310401940452.
Moshi FV, Millanzi WC, Mwampagatwa I (2021). Factors associated with uptake of iron supplement during pregnancy among women of reproductive age in Tanzania. Front. in Public Health. 9: 1–8. DOI: 10.3389/fpubh.2021.6040-58.
Murti B (2023). Penilaian kualitas studi primer untuk desain studi observasional cross-sectional dalam penelitian meta analisis (Primary study quality assessment for cross-sectional observational study designs in meta-analysis research)
Nigussie T, Negera E, Chali K, Regassa CR (2022). Adherence level to iron-folic acid supplement and associated factors among pregnant women attending antenatal care in selected public health facilities of Ilu Aba Bor Zone, Southwest. Int. J. Adv. Res. 5(5): 1-12.
Ridwan N, Shafi A (2021). Adherence to iron folate supplementation and associated factors among pregnant women attending antenatal care at public hospitals in Jigjiga Town, Somali Region, Ethiopia 2020. Pan Afr. Med. J. Conf. Proc. 40. DOI: 10.11604/pamj.2021.40.196.27958.
Sendeku FW, Azeze GG,Fenta SL (2020). Adherence to iron-folic acid supplementation among pregnant women in Ethiopia: A systematic review and meta-analysis. BMC Pregnancy Childbirth. 20(1): 1–9. DOI: 10.1186/s1288 402028350
Solomon Y, Sema A, Menberu T (2021). Adherence and associated factors to iron and folic acid supplementation among pregnant women attending antenatal care in public hospitals of Dire Dawa, Eastern Ethiopia. Eur. J. Midwifery. 5: 1–7. DOI: 10.18332/ejm/138595.
Tarekegn M, Wubshet M, Atenafu A, Derso T, Woretaw A (2019). Antenatal care and mothers education improved iron-folic acid adherence at Denbiya district health centers, Northwest Ethiopia: Using pills count method. Arch. Public Health. 77(1): 1-6. DOI: 10.1186/s13690-019-0356-y
Tefera AA, Ibrahim NA, Umer AA (2023). Adherence to iron and folate supplementation and associated factors among women attending antenatal care in public health facilities at Covid-19 pandemic in Ethiopia. PLOS Glob. Public Health, 3(1). DOI: 10.1371/journal.pgph.0000825.
Wemakor A(2019). Prevalence and determinants of anaemia in pregnant women receiving antenatal care at a tertiary referral hospital in Northern Ghana. BMC Pregnancy Childbirth.19(1):1–11. DOI: 10.23937/25723278/1510059
Barzilay S, Klomek AB, Apter A, Carli V, Wasserman C, Hadlaczky G, Hoven CW, et al. (2017). Bullying victimization and suicide ideation and behavior among adolescents in europe: A 10-Country Study’. J Adolesc Health, 61(2):79–186. doi: 10.1016/j.jadohealth.2017.02.002.
Benatov J, Klomek AB, Gal SC (2021). Bu-llying perpetration and victimization associations to suicide behavior: a longitudinal study. Eur Child Adolesc Psychiatry. doi: 10.1007/s00787021017769.
Center for Evidence Based Management (2014). Critical appraisal checklist for cross-sectional study. Retrieved from: https://www.cebma.org
Duan S, Duan Z, Li R, Wilson A, Wang Y, Jia Q, Yang Y, et al. (2020). Bullying victimization, bullying witnessing, bullying perpetration and suicide risk among adolescents: A serial mediation analysis. J. Affect. Disord, 273: 274-279. doi: 10.1016/j.jad.2020.03.143
Eze JE, Chukwuorji JC, Ettu PC, Zacchaeus EA, Iorfa SK, Nwonyi SK (2021). Bullying and suicide ideation: testing the buffering hypothesis of social support in a Sub-Saharan African Sample. J Child Adolesc Trauma. 14(1):19–27. doi: 10.1007/s4065301900294w.
Hertz MF, Wrigth J (2013). Bullying and suicide: a public health approach. J Adolesc Health, 53. doi: 10.1016/j.jadohealth.2013.05.002.
Holt MK, Vivolo AM, Polanin JR, Holland KM, DeGue S, Matjasko JL, Reid G (2015). Bullying and suicidal ideation and behaviors: A meta-analysis. Pediatrics, 135(2), e496-e509. doi: 10.1542/peds.2014-1864
Hong L, Guo L, Wu H, Li P, Xu Y, Gao X, Deng J, et al. (2016). Bullying, depression, and suicidal ideation among adolescents in the fujian province of China a cross-sectional study. Medicine. 95 (5): 1–6. doi: 10.1097/MD.0000000000002530.
Kanyinga HS, Roumeliotis P, Xu H (2014). Associations between cyberbullying and school bullying victimization and suicidal ideation, plans and attempts among Canadian schoolchildren, PLoS ONE, 9(7). doi: 10.1371-/journal.pone.0102145.
Kim YS, Koh YJ, Leventhal B (2015). School bullying and suicidal risk in Korean middle school students. -Pediatrics, 115(2): 357-363.
Koyanagi A, Oh H, Carvalho AF, Smith L, Haro JM, Vancampvort D, Stubbs B, et al. (2019). Bullying victimization dan suicide attempt among adolescents aged 12–15 years from 48 countries, J Am Acad Child Adolesc Psychiatry, 58(9): 907-918.e4. doi: 10.1016/j.jaac.2018.10.018.
Kreski NT, Chen Q, Olfson M, Cerda M, Hasin D, Martins SS, Mauro PM, et al (2021). Trends in adolescent online dan offline victimization dan suicide risk factors. Pediatrics. 148(3). doi: 10.1542/peds.2020049585.
Litwiller BJ, Brausch AM (2013). Cyber bullying and physical bullying in adolescent suicide: the role of violent behavior and substance use. J Youth Ado-lesc. 42(5):675-684. doi: 10.1007/s109640139925-5
Murti B (2018). Prinsip dan metode riset epidemiologi (5th ed) (Epidemiological research principles and methods). Program studi ilmu kesehatan masyarakat, program pascasarjana, Universitas Sebelas Maret.
Nguyen DT, Dedding C, Pham TT, Wright P, Bunders J (2013). Depression, anxiety, and suicidal ideation among Vietnamese secondary school students dan proposed solutions: A cross-sectional study, BMC Public Health. 13(1). doi: 10.1186/14712458131195
Peng C, Hu W, Yuan S, Xiang J, Kang C, Wang M, Rong F, et al. (2020). Self-harm, suicidal ideation, dan suicide attempts in chinese adolescents involved in different subtypes of bullying: A cross-sectional study. Front. Psyhiatry. 11:1–10. doi: 10.3389/fpsyt.2020.565364.
Peng Z, Klomek AB, Li L, Su X, Sillanmaki L, Chudal R, Sourdaner A (2019). Associations between Chinese adole-scents subjected to traditional dan cyber bullying and suicidal ideation, selfharm dan suicide attempts. BMC Psychiatry. 19(1): 1–8.
Rettew DC, Pawlowski S (2016). Bullying. Child Adolesc. Psychiatr. Clin. 25(2): 235-242. doi: 10.1016/j.chc.2015.12.-002.
Shayo FK, Lawala PS (2019). Does bullying predict suicidal behaviors among in-school adolescents? A cross-sectional finding from Tanzania as an example of a low-income country, BMC Psychiatry, 19(1): 1–6. doi: 10.1186/s1288801924022.
Ziaei R, Viitasara E, Soares J, Bazarghani HS, Dastgiri S, Zeinalzadeh AH, Mohammadi R (2017). Suicidal ideation and its correlates among high school students in Iran: a cross-sectional study. BMC psychiatry. 17(1):1-7. doi 10.1186/s128880171298y
