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The Effectiveness of Letrozole-Electroacupuncture Adjuvant Therapy in Reducing Resistance and Pulsatility Indices in Women with Polycystic Ovarian Syndrome

Dhamayanti Eka Octavia, Uki Retno Budihastuti, Eriana Melinawati, Nutria Widya Purna Anggraini, Eric Edwin Yuliantara, Ida Nurwati, Cahyono Hadi

Abstract

Background: Polycystic Ovarian Syndrome (PC­­­­OS) is a complex endocrine disorder and the cau­­­­se of 40% of infertility cases. In recent years, let­­­ro­zole as an aromatase inhibitor has been report­ed to be effective for ovulation induction. In addi­­tion, electro acupuncture therapy can redu­ce tonic activity in the sympa­thetic vaso­constric­tor path­­way to the uterus. This stu­dy aimed to determine the effectiveness of Let­ro­zo­le-Electroacupuncture adjuvant therapy in reducing the Resistance Index and Pul­sa­ti­li­ty Indices in women with Polycystic Ovary Syn­dro­me (PCOS).

Subjects and Method: This was an analytical ob­servational study with a cohort approach. The sub­jects of the study were women aged 20-45 years based on age, body mass index (BMI), and pe­riod of infertility aspects. The sample con­sisted of 30 people who were divided into 2 groups, name­­ly group 1 with letrozole therapy, while group 2 with additional electro­acu­punc­ture therapy and then carried out pre- and post-interven­tion exa­mi­nations on day 19 and 21. The depen­dent variables were the Resist­ance Index value and the Pulsaitility Index value. The inde­pendent vari­­ables were Letro­zole and Electro­acupuncture therapies. The Resistance and Pulsatility Indices we­re measured using USG transabdominal Color Dop­­pler Voluson P6. The data were analyzed using the Mann Whitney test.

Results: The Pul­satility Index for group 1 on day 21 (Mean= 2.69; SD= 0.87) was higher than group 2 (Me­an= 1.97; SD= 0.57), and it was statistically sig­ni­fi­cant (p= 0.013).

Conclusion: Letrozole-EA therapy reduce the Resistance and Pulsatility In­dices.

Keywords: Letrozole, acupuncture, endo­metrial re­ceptivity, Polycystic Ovarian Syndrome

Correspondence: Dhamayanti Eka Octavia. Department of Obs­tetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Ma­­ret/ Dr. Moewardi Hos­pital, Sura­kar­ta 57126, Central Java. Email: dhama­yan­ti­eka.de@gmail.com. Mobile: 08125­0355886.

Journal of Maternal and Child Health (2020), 05(04): 422-429
https://doi.org/10.26911/thejmch.2020.05.04.09

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