Comparison of Pregnancy Loss Proportions Between Pregnant Women with Mild and Moderate-Severe Systemic Lupus Erythematosus
DOI:
https://doi.org/10.26911/thejmch.2024.09.05.06Abstract
Background: Pregnancy in systemic lupus erythematosus (SLE) patients is considered high-risk due to potential negative impacts on both the mother and fetus, such as pregnancy loss. One of the factors influencing pregnancy loss in SLE patients is increased lupus activity and antiphospholipid syndrome (APS). This study aimed to evaluate the relationship between pregnancy loss and SLE disease activity levels.
Subjects and Method: This cross-sectional study conducted at Dr. Moewardi Hospital. The population consisted of pregnant women with SLE treated at RSUD Dr. Moewardi between 2021 and 2023. A total of 81 pregnant patients with SLE selected through purposive sampling. The dependent variable was pregnancy loss. The independent variable was pregnant women with SLE. This study utilized tools and materials in the form of medical record data from the Obstetrics and Gynecology Department at Dr. Moewardi Hospital, Surakarta. Data were analyzed using bivariate analysis with SPSS software and Fisher’s exact test tests.
Results: A total of 81 respondents meeting the inclusion criteria were included, consisting of 66 pregnant women with mild SLE activity and 15 pregnant women with moderate-to-severe SLE activity. There was no significant relationship between the degree of systemic lupus erythematosus activity and pregnancy loss (p =0.723).
Conclusion: There is no significant association between pregnancy loss and the degree of systemic lupus erythematosus activity, whether mild or moderate-severe.
Keywords:
systemic lupus erythematosus, pregnancy loss, pregnant womenReferences
Ceccarelli F, Pirone C, Perricone C, et al. (2020). Pregnancy outcome in systemic lupus erythematosus patients: a monocentric cohort analysis. Rheumatology. 60(4):1747-1754. https://doi.org/10.1093/rheumatology/keaa470.
Clark C, Spitzer K, Laskin C (2005). Decrease in pregnancy loss rates in patients with systemic lupus erythematosus over a 40-year period. J Rheumatol. 32(9):1709-12. https://pubmed.ncbi.nlm.nih.gov/16142865/.
Clowse ME (2007). Lupus activity in pregnancy. Rheum Dis Clin North Am. 33(2): 237-52. https://doi.org/10.1016/j.rdc.2007.01.002.
Clowse M, Magder L, Witter F, Petri M (2005). The impact of increased lupus activity on obstetric outcomes. Arthritis Rheum. 52(2):514-21. https://doi.org/10.1002/art.20864.
Fussman C, Mckane P (2014). The prevalence of infertility and pregnancy loss in Michigan. Michigan BRFSS Surveillance Brief. 8(1). Lansing, MI: Michigan Department of Community Health, Lifecourse Epidemiology and Genomics Division, Surveillance and Program Evaluation Section, Chronic Disease Epidemiology Unit.
Departemen Kesehatan (2017). Infodatin lupus (Lupus infodata).
Indonesian Rheumatology Association (2019). Diagnosis dan pengelolaan lupus eritematosus sistemik (Diagnosis and management of systemic lupus erythematosus). Retrieved from https://reumatologi.or.id/wpcontent/uploads/2020/10/Diagnosis_dan_pengelolaan_SLE.pdf
Khairani N, Wijayati PS, Utomo AW (2018). Karakteristik kehamilan dengan lupus eritematosus sistemik di RSUP Dr. Kariadi Semarang (Characteristics of pregnancy with systemic lupus erythematosus at Dr. Kariadi General Hospital, Semarang). Jurnal Kedokteran Diponegoro. 7(2): 1457-1469. https://doi.org/10.14710/dmj.v7i2.21464.
Muthusamy V (2017). Systemic lupus erythematous (SLE). Thesis. Fakultas Kedokteran: Universitas Udayana.
Octavia H, Fauzy RR, Pratama MF, Siahaan SC (2022). Systemic lupus erythematosus in pregnancy: The New Challenge. Proceedings: Back to the Basic, Heart-Based Education as Fundamental Aspect in Medical Education. Retrieved from https://prosiding.karyasains.or.id/index.php/AFKSI2022/article/view/14.
Pinzon R, Edi DR, Prabantini D (2021). Metodologi penelitian kesehatan (Health research methodology). Yogyakarta: Penerbit ANDI.
Tanzilia MF, Tambunan BA, Dewi DS (2021). Tinjauan pustaka: patogenesis dan diagnosis sistemik lupus eritematosus (Literature review: pathogenesis and diagnosis of systemic lupus erythematosus). Syifa’ Medika: Jurnal Kedokteran dan Kesehatan. 11(2): 136-164. https://doi.org/10.32502/sm.v11i2.2788.
