The Effectiveness of Fish Oil and Ginger Drink in Reducing Dysmenorrhea: A Meta Analysis


  • Isnaini Novitasari Masters Program in Public Health, Universitas Sebelas Maret
  • Eti Poncorini Pamungkasari Faculty of Medicine, Universitas Sebelas Maret
  • Hanung Prasetya Health Polytechnics, Ministry of Health Surakarta


Background: Dysmenorrhea causes 34-50% of women to be unable to work in the workplace and 40% of adolescent girls are absent from school. Fish oil and ginger are used as alter


Anonim (2017). Standard for Fish Oils. Codex Alimentarium Comission 329: 1

Behboudi-GS, Hariri FZ, Moghaddam-BL (2018). The effect of Omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: A randomized clinical trial. J Psychosom Obstet Gynaecol. 39(4): 266

Charbel-AD, James R (2010). Drug interactions with garlic and ginger supplements. Herbal Supplements: efficacy, toxicity, interactions with western drugs, and effects on clinical laboratory tests. 333

Chatterjee S, Judeh ZMA (2016). Micro-encapsulation of fish oil. Lipid Technology 28(1): 13

Chen CX, Draucker CB, Carpenter JS (2018). What women say about their dysmenorrhea: A qualitative thematic analysis. BMC Women

Christophersen P, Yang M, Mu H (2016). Effects of microencapsulation on bio-availability of fish oil Omega-3 fatty acids. Encapsulation and Controlled Release Technologies in Food Systems. Second Edition: 309

Corte LD, Di FC, Gabrielli O, Rapuccia S, La VLS, Ragusa R, Fichera M, Commodari E, Bifulco G, Giampaolino P (2020). The burden of endometriosis on women

Daily JW, Zhang X, Kim DS, Park S (2015). Efficacy of ginger for alleviating the symptoms of primary dysmenorrhea: A systematic review and meta-analysis of randomized clinical trials. Pain Med. 16(12): 2243

Davaneghi S, Tarighat-EA, Safaiyan A, Fardiazar Z (2017). The effects of n-3 fatty acids and Rosa damascena extract on primary dysmenorrhea. 19(1): 34

Durmu? M (2019). Fish oil for human health: Omega-3 fatty acid profiles of marine seafood species. Food Sci Technol. 39(2): 454

Ernawati S, Nonon SS, Nailus S, Ummu S, Agusniar TSL (2017). Manajemen kesehatan menstruasi (Menstrual health management). Universitas Nasional IWWASH Global One.

Ferries-RE, Corey E, Archer JS (2020). Primary dysmenorrhea: Diagnosis and therapy. Obstetrics and gynecol. 136(5): 1047

Fletcher J (2020). Why is ginger good for you? Medical News Today. Accessed from Content

Gow R (2020). Cycle of salmon. Columbia Journal. Retrieved from http://colum biajournal. org /cycle-of-salmon/

Harel Z (2008). Dysmenorrhea in adolescents and young adults: from pathophysiology to pharmacological treatments and management strategies. Expert Opin Pharmacother. 9(15): 2661

Hawker GA, Mian S, Kendzerska T, and Hawker GA, Mian S, Kendzerska T, French M (2011). Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care Res (Hoboken). 63(11): 240

Hernandez EM (2015). Omega 3 Oils and Blends. Trait-Modified Oils in Foods: 169

Hilleman DE, Teply R, Packard KA (2020). Knowledge, perceptions, and patterns of fish oil use in cardiac patients. J Pharm Pract. 33(5): 580

Hosseinlou A, Alinejad V, Alinejad M, Aghakhani N (2014). The effects of fish oil capsules and vitamin B1 tablets on duration and severity of dysmenorrhea in students of high school in Urmia-Iran. Glob J Sci. 6(7): 124

Jacobsen C (2014). Omega-3 Fatty Acid-Enriched Foods: Health Benefits and Challenges. Wiley-Blackwell. 8: 153-172.

Jenabi E (2013). The effect of ginger for relieving of primary dysmenorrhoea. J Pak Med Assoc. 63(1):8-10. PMID: 23865123.

Kashefi F, Khajehei M, Tabatabaeichehr M, Alaviniam M, Asili J (2014). Comparison of the effect of ginger and zinc sulfate on primary dysmenorrhea: a placebo-controlled randomized trial. Pain Manage Nurs. 15(4): 826

Khayat S, Kheirkhah M, Behboodi M, Fanaei H, Kasaeian A, Javadimehr M (2014). Effect of treatment with ginger on the severity of premenstrual syndrome symptoms. ISRN Obstetrics and Gynecology, 2014, 1

Kheirkhah M, Gholami R, Ghare-SSY, Hanieh A (2016). Comparison of the effect of omega-3 fatty acids and perforan (Hypericum perforatum) on severity of premenstrual syndrome (PMS): A randomized trial. Int J Med Res Health Sci. (1): 333

Keogh MK, O'Kennedy BT, Kelly J, Auty MA, Kelly PM, Fureby A, Haahr AM (2001). Stability of oxidation of spraydried fish oil powder micro-encapsulated using milk ingredients. J Food Sci. 66(2): 217-224.

Mehrpooya M, Eshraghi A, Rabiee S, Larki-HA, Ataei S (2017). Comparison the effect of fish-oil and calcium supple-mentation on treatment of primary dysmenorrhea. Rev Recent Clin Trials. 12(3): 1

Najafi N, Khalkhali H, Tabrizi FM, Zarrin R (2018). Major dietary patterns in relation to menstrual pain: A nested case control study. BMC Women

Nodler JL, Divasta AD, Vitonis AF, Karevicius S, Malsch M, Sarda V, Fadayomi A, Harris HR, Missmer, Stacey A (2020). Supplementation with Vita-min D or ?-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): A double-blind,

randomized, placebo-controlled trial. Am J Clin Nutr. 112(1): 229

Novitasari E, Soemanto RB, Prasetya H (2020). Effect of acupuncture therapy on pain reduction in dysmenorrhea patients: A meta-analysis. J Matern Child Health. 05(6): 705

Pagano E, Souto EB, Durazzo A, Sharifi?RJ, Lucarini M, Souto SE, Salehi B, et al. (2020). Ginger (Zingiber Officinale Roscoe) as a Nutraceutical: Focus on the metabolic, analgesic, and anti-inflammatory effects. Phytother Res. 1

Pakniat H, Chegini V, Ranjkesh F, Hosseini MA (2019). Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: A single-blind clinical trial. Obstet Gynecol Sci. 62(6): 462

Petraglia F, Bernardi M, Lazzeri L, Perelli F, Reis FM (2017). Dysmenorrhea and Related Disorders. F1000Res. 6: 1

Pratap SRV, Gangadharappa HV, Mruthun-jaya K (2017). Ginger: A potential neutraceutical, an updated review. Int J Pharmacogn Phytochem Res. 9(9): 1227

Rahbar N, Asgharzadeh N, Ghorbani R (2012). Effect of Omega-3 fatty acids on intensity of primary dysmenorrhea. Int J Gynecol Obstet. 117(1): 45

Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M (2012). Effect of Zingiber Officinale R. Rhizomes (ginger) on pain relief in primary dysmenorrhea: A placebo randomized trial. BMC Complement Altern Med. 12: 92.

Richards L (2020). Are sardines good for you? Medical news today. tersedia di

Sadeghi N, Paknezhad F, Rashidi NM, Kavianpour M, Jafari RS, Khade HH (2018). Vitamin E and fish oil, separately or in combination, on treatment of primary dysmenorrhea: A double-blind, randomized clinical trial. Gynecol Endocrinol. 34(9): 804

Saha SN, Tiwari A, Patel YK, Bihari A, Vishwavidyalaya V, Ghasida (2020). Ginger physico chemical properties and it

Schaultz H (2016). Despite Generally Good Reputation Peruvian Anchovy Fishery Still Not MSC Certified. News Analysis on Supplement Health and Nutrition

Shirooye P, Hashem-DF, Hamzeloo-MM, Afrakhteh M, Bioos S, Mokaberinejad R (2017). A clinical comparative study of oral and topical ginger on severity and duration of primary dysmenor-rhea. Res J Pharmacogn. 4(1): 23

Shirvani MA, Motahari-Tabari N, Alipour A (2014). The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: A randomized clinical trial. Arch Gynecol Obstet. 291(6): 1277

Shirvani MA, Motahari-Tabari N, Alipour A (2017). Use of ginger versus stretching exercises for the treatment of primary dysmenorrhea: a randomized controlled trial. J Integr Med. 15(4): 295

Sinaga E, Nonon S, Suprihatin, Sa

Smithers R (2018). Good fish guide calls for consumers to move away from cod, haddock, salmon and prawn in favour of sustainable choice. The Guardian. Tersedia di https://www.

Sohrabi N, Kashanian M, Ghafoori SS, Malakouti SK (2013). Evaluation of the effect of Omega-3 fatty acids in the treatment of premenstrual syndrome: A pilot trial. Complement Ther Med. 21(3): 141

Stepko B (2019). The Full Story on Fish Oil.

Sultan S, Ahmed Z, Afreen A, Rashid F, Majeed F, Khalid N (2020). Analgesic effect of ginger and peppermint on adolescent girls with primary dysmenorrhea. Food Sci Technol. 2061: 1

Sutapa P, Alagh P, Rana M (2017). Experimental study to compare the effectiveness of progressive muscle relaxation versus oral intake of ginger powder on the selected symptoms of dysmenorrhoea among the nursing students. Nurs J India. 6(4): 2049




How to Cite

Novitasari, I., Pamungkasari, E. P., & Prasetya, H. (2021). The Effectiveness of Fish Oil and Ginger Drink in Reducing Dysmenorrhea: A Meta Analysis. Journal of Maternal and Child Health, 6(3), 353–364. Retrieved from