Meta-Analysis: The Effect of Anxiety During Pregnancy on the Risk of Premature Birth and Low Birth Weight in Infants


  • Amalia Ulfah Suparno Masters Program in Public Health, Universitas Sebelas Maret
  • Uki Retno Budihastuti Department of Obstetric and Gynecology, Dr. Moewardi Hospital/ Faculty of Medicine, Universitas Sebelas Maret
  • Bhisma Murti Masters Program in Public Health, Universitas Sebelas Maret


Background: Pregnancy can be defined as the process of meeting spermatozoa with the ovum which is followed by attachment of the embryo to the uterine wall, in the process of pregnancy according to some or almost all women it becomes a happy process or causes anxiety due to the occurrence of many physiological and psychological changes, so that if it is not treated seriously then will have an impact on the baby such as premature birth and low birth weight. This study aims to estimate the magnitude of the effect of anxiety during pregnancy on premature birth and low birth weight with a meta-analysis study.

Subjects and Method: This was a meta-analysis and systematic review conducted with PRISMA flow diagrams. Population= pregnant women, Intervention= anxiety, Comparison= not anxious, Outcomes= premature birth and low birth weight. Search articles through journal databases include: Google Scholar, PubMed, Science Direct. The articles used in this study are articles that have been published from 2000-2021. The keywords to search for articles were as follows:


Alipour Z, Lamyian M, Hajizadeh E. (2012). Anxiety and fear of childbirth as predictors of postnatal depression in nulliparous women. Women and Birth, 25(3): e37

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Chandra PS, Bajaj A, Desai G, Satyanarayana VA, Sharp HM, Ganjekar S, S-upraja TA, Jangam KV, Venkatram L, Kandavel T (2021). Anxiety and depressive symptoms in pregnancy predict low birth weight differentially in male and female infants

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Gibson-Smith D, Bot M, Milaneschi Y, Twisk JW, Visser M, Brouwer Ia, Penninx BWJH (2015). Maternal anxiety during pregnancy and the association with adverse perinatal outcomes: Systematic review and meta-analysis. Journal of Clinical Psychiatry. 77: 22

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Nasreen HE, Pasi HB, Rifin SM, Aris MAM, Rahman JA, Rus RM, Edhborg M. (2019). Impact of maternal antepartum depressive and anxiety symptoms on birth outcomes and mode of delivery: A prospective cohort study in east and west coasts of Malaysia. BMC Pregnancy and Childbirth, 19(1): 1

Pavlov M, Steiner N, Kessous R, Weintraub AY, Sheiner E (2014). Obstetric and neonatal outcome in patients with anxiety disorders. Journal of Maternal-Fetal and Neonatal Medicine, 27(13), 1339

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Taheri PA, Goudarzi Z, Shariat M, Nariman S, Matin EN (2018). The effect of a short course of moderate pressure sunflower oil massage on the weight gain velocity and length of NICU stay in preterm infants. Infant Behavior and Development, 50: 22

Yonkers KA, Gilstad-Hayden K, Forray A, Lipkind HS (2017). Association of panic disorder, generalized anxiety disorder, and Benzodiazepine Treatment during pregnancy with risk of adverse birth outcomes. JAMA Psychiatry. 74(11): 1145




How to Cite

Suparno, A. U., Budihastuti, U. R., & Murti, B. (2021). Meta-Analysis: The Effect of Anxiety During Pregnancy on the Risk of Premature Birth and Low Birth Weight in Infants. Journal of Maternal and Child Health, 6(5), 580–591. Retrieved from