Meta-Analysis the Effect of Hormonal Contraception on the Weight Gain and Hypertension in Women of Reproductive Age


  • Zonna Aditiya Kusumaningtiyas Master's Program in Public Health, Universitas Sebelas Maret
  • Didik Tamtomo Faculty of Medicine, Universitas Sebelas Maret
  • Bhisma Murti Master's Program in Public Health, Universitas Sebelas Maret



Background: Hormonal contraception is a contraceptive method that can prevent pregnancy because it contains estrogen and progesterone. The use of hormonal contraception for a long time can cause side effects including increased body weight, cholesterol deposits, and hypertension. The purpose of this study was to examine, analyze, and estimate the magnitude of the effect of the use of hormonal contraception on the incidence of weight gain and hypertension in women of childbearing age based on the results of previous similar studies.

Subjects and Method: This study is a systematic review and meta-analysis using PRISMA flowchart diagrams. The process of searching for articles was carried out between 2004-2021 using 3 databases, including Google Scholar, PubMed, and Science Direct. The keywords used in the database search are ""Hormonal Contraception" AND “DPMA injection” AND "Weight Gain" AND "Hypertension". Inclusion criteria for full text articles used the observational Randomized Controlled Trial method, the articles used English, and reported the Mean and SD in multivariate analysis. Articles that met the requirements were analyzed using the RevMan 5.3 application.

Results: A total of 14 articles with a Randomized Controlled Trial study design originating from Thailand, Indonesia, Pakistan, America, California, Africa, Ethiopia, and Kenya were meta-analyzed in this study. Meta-analysis of 7 articles showed that hormonal contraception had an effect on weight gain in women of childbearing age by 0.03 units but not statistically significant (SMD= 0.03; 95% CI= 0.07 to 0.14; p= 0.530). Meanwhile, 7 articles showed that hormonal contraception increased the incidence of hypertension in women of childbearing age by 0.10 units, but it was not statistically significant (SMD= 0.10; 95% CI= 0.17 to 1.37; p= 0.460).

Conclusion: Hormonal contraception increases body weight and hypertension in women of childbearing age.

Keywords: hormonal contraception, weight gain, hypertension, meta-analysis.

Correspondence:Zonna Aditiya Kusumaningtiyas. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: Mobile: +628­2­234998054.


Aasare GA, Santa S, Angala RA, Asiedu B, Afriyie D, Amoah AG. (2014). Effect of hormonal contraceptives on lipid profile and the risk indices for cardio-vascular disease in a ghanaian community. Int J Womens Health 6(1), 597–603. Doi: 10.2147/IJWH.S59852

Ardiani K, Nursucahyo E, Prijambodo T, Anas M (2020). Comparison of weight gain in injectable contraceptive 1-month and 3-month acceptors at the independent midwife practice Tambaksari Surabaya. MAGNA MEDICA: Berkala Ilmiah Kedokteran Dan Kesehatan, 7(2), 63. Doi: 10.26714/magnamed.7.2.2020.63-69

Baziad A (2008). Kontrasepsi hormonal (Hormonal contraception). PT Bina Pustaka Sarwono Prawirohardjo.

Beksinska ME, Smit JA, Kleinschmidt I, Milford C, Farley TMM (2010). Prospective study of weight change in new adolescent users of DMPA, NETEN, COCs, nonusers and discontinuers of hormonal contraception. Contraception, 81(1), 30–34. Doi: 10.1016/j.contraception.2009.07.007

Berenson AB, Rahman M (2009). Changes in weight, total fat, percent body fat, and central-to-peripheral fat ratio associated with injectable and oral contraceptive use. Am. J. Obstet. Gynecol. 200(3), 329.e1-329.e8. Doi: 10.1016/j.ajog.2008.12.052

Bonny AE, Britto MT, Huang B, Succop P, Slap GB. (2004). Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA). J Pediatr Adolesc Gynecol 17(2), 109–115. Doi:10.1016/j.jpag.2004.01.006

Bonny AE, Ziegler J, Harvey R, Debanne SM, Secic M, Cromer BA (2006). Weight gain in obese and nonobese adolescent girls initiating depot medroxyprogesterone, oral contraceptive pills, or no hormonal contraceptive method. Arch. pediatr. adolesc. med, 160(1), 40–45. Doi: 10.1001/archpedi.160.1.40

Clark MK, Dillon JS, Sowers M, Nichols S (2005). Weight, fat mass, and central distribution of fat increase when women use depot-medroxyprogesterone acetate for contraception. Int J Obes (Lond), 29(10), 1252–1258. Doi: 10.1038/sj.ijo.0803023

Hariadini AL, Wijayati AI, Pramestutie HR, Kurnia R (2017). Side effect experienced by the acceptor of oral contraceptive and the number of repeated visit to health professionals: an overview (A prestudy in creating “ Sukses Ber - KB” computer application at Pharmacies in Malang). Pharm. j. Indones, 3(1), 17–23

Haroon S, Naveed AK (2014). Effect of hormonal contraceptives on serum electrolytes and blood pressure. J. Postgrad. Med. Inst. 28(4), 409–413.

Huang X, Li Y, Huang Z, Wang C, Xu Z (2014). Pai-1 Gene variants and COC use are associated with stroke risk: a case-control study in the han chinese women. Mol. Neurobiol.54(4), 803–810. Doi:10.1007/s1203101404180

Jirakittidul P, Somyaprasert C, Angsuwathana S (2019). Prevalence of documented excessive weight gain among adolescent girls and young women using depot medroxyprogesterone acetate. J. Clin. Med. Res. 11(5),326–331. Doi:10.14740/jocmr3792

Martuti A (2009). Merawat dan menyembuhkan hipertensi penyakit tekanan darah tinggi (Treating and curing hypertension for high blood pressure). Kreasi Wacana.

Murayama N, Matsunaga A, Tangbanluekal L, Tantawiwat S, Ohtsuka R (2003). Effects of oral contraceptive use on body mass index and blood pressure among female villagers in North-east Thailand. J. Biosoc. Sci.35(2), 243–261. Doi: 10.1017/S0021932003002438

Rufaridah A, Putri K, Cumayunaro A, Sidaria S (2017). Perbedaan indeks massa tubuh pada akseptor kb suntik 1 dan 3 bulan (Differences in body mass index in injectable kb acceptors 1 and 3 months). Jurnal Endurance, 2(3), 270. Doi:10.22216/jen.v2i3.1975

Ryan KA, Cole JW, Saslow K, Mitchell BD, McArdle PF, Sparks MJ, Cheng YC, Kittner SJ (2014). Prevention opportunities for oral contraceptive Associated ischemic stroke. Stroke, 45(3), 893–895. Doi: 10.1161/STROKEAHA.113.004023

Shiferaw M, Kassahun W, Zawdie B (2021). Anthropometric indices, blood pressure, and lipid profile status among women using progestin-only contraceptives: comparative cross-sectional study. BMC Women’s Health, 21(1), 1–9. Doi:10.1186/s12905021011788

Siegerink B, Meltzer ME, De Groot PG, Algra A, Lisman T, Rosendaal, FR. (2012). Clot lysis time and the risk of myocardial infarction and ischaemic stroke in young women; results from the RATIO case-control study. Br. J. Haematol, 156(2), 252–258. Doi: 10.1111/j.1365-2141.2011.08935.x

Urbanus RT, Siegerink B, Roest M, Rosendaal FR, de Groot PG, Algra A. (2009). Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study. The Lancet Neurology, 8(11), 998–1005.

Wang C, Li Y, Li H, Sun T, Jin G, Sun Z, Zhou J, Ba L, Huang Z, Bai J. (2012). Increased risk of stroke in oral contraceptive users carried replicated genetic variants: A population-based case-control study in China. Human Genetics, 131(8), 1337–1344. Doi: 10.1007/s0043901211617

Wanyoike Gichuhi JKAW, BOJ Wanyoike Gichuhi OJ, Referral M, Hospital Eldoret Kenya Oyieke BOTJ, Wanyoike Gichuhi MBChb, J (2014). The effect of depot medroxyprogesterone acetate contraceptive on body weight and blood pressure in indige-nous kenyan women. Int. j. sci. technol. manag, 3(6), 37–46.

Xiang AH, Kawakubo M, Buchanan TA, Kjos SL (2007). A longitudinal study of lipids and blood pressure in relati-on to method of contraception in Latino women with prior gestational diabetes mellitus. Diabetes Care, 30 (8), 1952–1958. Doi:10.2337/dc070180

Xu Z, Li Y, Huang X, Shen W, Bai J, Shen C, Zhao Y (2017). ESR2 Genetic Vari-ants and combined oral contraceptive use associated with the risk of stroke. Archives of Medical Research, 48(2), 203–211. Doi: 10.1016/j.arcmed.2017.03.015

Zerihun MF, Malik T, Ferede YM, Bekele T, Yeshaw Y (2019). Changes in body weight and blood pressure among women using Depo-Provera injection in Northwest Ethiopia. BMC Research Notes, 12(1), 1–5. Doi: 10.1186/s131040194555y




How to Cite

Kusumaningtiyas, Z. A., Tamtomo, D., & Murti, B. (2022). Meta-Analysis the Effect of Hormonal Contraception on the Weight Gain and Hypertension in Women of Reproductive Age. Journal of Maternal and Child Health, 7(6), 699–710.