The Role of Ferritin Serum Level as Predictor Sepsis Mortality on Children in Dr. Moewardi Hospital of Surakarta
DOI:
https://doi.org/10.26911/thejmch.2023.08.02.08Abstract
Background: Sepsis cause death in the worldwide pediatric population. Eestablishing the diagnosis of sepsis in children is challenging because the symptoms are varied and not specific. Serum ferritin is an acute phase protein which can be elevated in sepsis. This study aimed to determine the role of ferritin level as a predictor for sepsis mortality in pediatric patient
Subjects and Method: A cross sectional study was conducted in children aged between 1 months and 18 years old diagnosed with sepsis who were treated at Dr. Moewardi General Hospital, Surakarta from November 2021 to April 2022. The statistical analysis used SPSS 25 with p<0.05 was considered significant. The cut off point of serum ferritin level was determined with ROC curve.
Results: A cross sectional study was conducted in children aged between 1 months and 18 years old diagnosed with sepsis who were treated at Dr. Moewardi General Hospital, Surakarta from November 2021 to April 2022. The statistical analysis used SPSS 25 with p<0.05 was considered significant. The cut off point of serum ferritin level was determined with ROC curve.
Conclusion: Serum ferritin level can be predictor of mortality in children with sepsis.
Keywords: ferritin, mortality in sepsis, children.
Correspondence: Agus Sucianto. Department of Pediatrics, Sebelas Maret University/ Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia. Kolonel Sutarto Street No. 132, Surakarta, Indonesia. Email: sucianto22@gmail.com. Mobile: 081227595134.
References
Anderson GJ, Frezer DM (2017). Current understanding of iron homeostasis. Am J Clin Nutr.106:1559–66.
Atjo S, Bahrun U, Hardjoeno (2015). Analisis kadar serum feritin di karsinoma payudara (Analysis of serum ferritin levels in breast carcinoma) Ind J Clinical Pathology and Medical Laboratory: 22:34-7.
Chiou B, Connor JR (2018). Emerging and Dynamic Biomedical Uses of Ferritin. Pharmaceuticals (Basel). 11(4):124. doi:10.3390/ph11040124. PMID: 30-428583; PMCID: PMC6316788.
Kernan KF, Carcillo JA (2017). Hyperferritinemia and inflammation. Int Immunol. 29(9):401-409. doi: 10.1093/intimm/dxx031. PMID: 28541437; PMCID: PMC5890889.
Mathias B, Mira JC, Larson SD (2016). Pediatric sepsis. Curr Opin Pediatr. 28(3):380-7. doi: 10.1097/MOP.0000000000000337. PMID: 26983000; PMCID: PMC4913352.
Sharma J, Sharma R (2018). Serrum ferritin: a prognostic marker in patients with sepsis in pediatric age group: a prospective cohort study. Int J Medical Health Research. 4(3):86-89. Retrieved from: http://www.medicalsciencejournal.com/archives/2018/vol4/ issue3/4236
Tonial CT, Costa CAD, Andrades GRH, Crestani F, Einloft PR, Bruno F, Miranda AP, et al. (2020). Prediction of poor outcomes for septic children according to ferritin levels in a middle-income setting. pediatr Crit Care Med. 21(5):e259-e266. doi: 10.1097/PCC.0000000000002273. PMID: 32343115.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, et al. (2020). Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. 21(2): e52-e106. doi: 10.1097/PCC.0000000000002198.
Williams V, Menon N, Bhatia P, Biswal M, Sreedharanunni S, Rawat A, Jayashree M, Nallasamy K (2020). Serum ferritin predicts neither organ dysfunction nor mortality in pediatric sepsis due to tropical infections. Front Pediatr. 8:607673. doi: 10.3389/fped.2020.607673. PMID: 33344390; PMCID: PMC7747694.
Yo CH, Hsu TC, Gabriel Lee MT, Porta L, Tsou PY, Wang YH, et al. Trend and outcome of sepsis in children: A nationwide cohort study. J Paediatr Child Health. 54(7):776-783. doi: 10.1111/jpc.13849.