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Meta-Analysis: The Effect of Malaria Infection on the Incidence of Low Birth Weight

Feri Yuda Anggara, Setyo Sri Rahardjo, Bhisma Murti

Abstract

Background: Malaria is a parasitic infectious disease. Malaria contributes to morbidity and mortality in high-risk groups, namely pregnant women and children under five. Malaria infec­tion during pregnancy can adversely affect both the mother and the fetus, including maternal anemia, miscarriage, preterm labor, intra­uterine growth retardation, and the delivery of infants with low birth weight (LBW). This study aims to analyze the magnitude of the influence of malaria infection on the incidence of LBW by a meta-analysis study.

Subjects and Method: This was a systematic review and meta-analysis conducted by follow­ing the PRISMA flow diagram. The process of searching for articles is carried out through a journal database which includes: PubMed, Springer Link, Google Scholar and Science Direct by selecting articles published in 2000-2020. Keywords used include: “Malaria infec­tion AND low birth weight", "malaria during pregnant "AND" low birth weight", "malaria during pregnant AND low birth weight AND adjusted ratio". The inclusion criteria were full paper articles with observational study design, articles using English, multivariate analysis used with adjusted odds ratio. Articles that meet the requirements are analyzed using the Revmen5.3 application.

Results: Thirteen articles were reviewed in this study with a cohort and cross-sectional study design. Meta-analysis of 4 cohort studies showed that pregnant women with malaria infection had a 1.31 times increased risk of low birth weight compared with those without malaria infection (aOR= 1.31; 95% CI= 0.90 to 1.90; p= 0.15). A meta-analysis of 9 cross-sectional studies showed that pregnant women with malaria infection had a 2.11 times increased risk of low birth weight compared with those without malaria infection (aOR= 2.11; 95% CI= 1.33 to 3.33; p= 0.001).

Conclusion: Malaria infection increases the risk of low birth weight.

Keywords: malaria infection, low birth weight

Correspondence: Feri Yuda Anggara. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: feriyudha90@gmail.com. Mobile: 085­220426805.

Journal of Maternal and Child Health (2020), 05(05): 549-562
https://doi.org/10.26911/thejmch.2020.05.05.09.

 

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