Factors Associated with Breast Cancer in Women of Reproductive Age at Dr. Pirngadi Hospital, Medan, North Sumatera

Mila Trisna Sari, Sorimuda Sarumpaet, Fazidah Aguslina Siregar


Background: Breast cancer has the highest prevalence in Indonesia. The objective of the research was to analyze the risk factors which influenced the incidence of breast cancer in women of reproductive age.

Subjects and Method: This was a case-control study conducted at Dr. Pirngadi Hos­pital, North Sumatera. The population was all 15-49 year-old breast cancer women. Sample of 42 women of reproductive age with breast cancer and 42 women without breast cancer was selected for this study. The dependent vari­able was breast cancer. The independent vari­ables were family history of breast cancer, menarche, history of breastfeeding, and history of fibrocystic disease. The data were collected by questionnaire and medical record. The data were analyzed by a multiple logistic regression.

Results: History of family with breast cancer (OR= 4.93; 95% CI=1.33 to 18.28), age of menstruation (OR= 8.46; 95% CI=2.34 to 30.64), history of breastfeeding (OR= 8.46; 95% CI= 2.19 to 32.70), and history of fibro­cystic disease (OR= 7.12; 95% CI=1.99 to 25.48) were associated with breast cancer.

Conclusion: History of family with breast cancer, age of menstruation, history of breast­feeding, and history of fibrocystic disease are associated with breast cancer.

Keywords: breast cancer, history of breastfeeding, women of reproductive age

Correspondence: Mila Trisna Sari. Masters Program in Public Health, Universitas Sumatera Utara. Email: Mobile: 08192100­173

Journal of Maternal and Child Health


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Anstey EH, Shoemaker ML, Barrera CM, O'Neil ME, Verma AB, Holman DM (2017). Breastfeeding and breast cancer risk reduction: Implications for black mothers. Am J Prev Med. 53(3): S40–S46. doi:10.1016/j.amepre.2017-.04.024.

Anothaisintawee T, Wiratkapun C, Lerd-sitthichai P, Kasamesup V, Wong-waisayawan S, Srinakarin J, Hirunpat S, et al. (2013). Risk factors of breast cancer: A systematic review and meta analysis. J Publich Health. 25(5): 368-387. doi:10.1177/1010539513488795

Brentnall AR, Cuzick J, Buist DSM, Bowles EJA (2018). Long-termaccuracy of breast cancer risk assessment combining classic risk factors and breast density. JAMA Oncol. 4(9):e180174.

Dinkes Kota Medan (2016). Profil Kesehatan Kota Medan Tahun 2016. Dinas Kesehatan Kota Medan; Medan.

Globacan En Ellatar (2011). Breast Cancer Epidemiology. Diakses Pada Tanggal 12 Maret 2018. Dapat Diakses di http://Breastcancer.Org/Symptoms/Understand_Bc/Statistics

IndriatiR (2005). Faktor-faktor risiko yang berpengaruh terhadap kejadian kanker payudara wanita. Tesis. Universitas Diponegoro. Semarang.

Lanfranchi A, Brind J (2005). Breast can-cer: Risk and prevention. 4th Edition, Pounhkeepsie: New York.

Lee A, Mavaddat N, Wilcox AN, Cunningham AP, Carver T, Hartley S, de Villiers CB, et al. (2018). BOADICEA: a comprehensive breast cancer risk prediction model incorporating gene-tic andnongenetic risk factors. Genetic Med. 21(8):1708-1718.

Li B, Wang L, Lu MS, Mo XF, Lin FY, Ho SC, Zhang CX (2015).Passive smoking and breast cancer risk among non-smoking women: A case-control study in China. PLOS one. 10(4): e0125894.

Kapoor PM, Lindström S, Behrens S, Wang X, Michailidou K, Bolla MK, WangQ, et al. (2020). Assessment of interactions between 205 breast cancer sus-ceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer

Association Consortium. Int J Epidemiol. 49(1):1-15.

Khodarahmi M, Azadbakht L (2015). The association between different kinds of fat intake and breast cancer risk in women. Int J Prev Med. 5(1):6-15.

Kemenkes RI (2014). Bulan Peduli Kanker Payudara. Infodatin Kemenkes RI. Jakarta

Kemenkes RI (2016). Bulan Peduli Kanker Payudara. Infodatin Kemenkes RI. Jakarta.

Kemenkes RI (2017). Profil Kesehatan Indonesia Tahun 2017. Kemenkes RI. Jakarta.

Maas P, Barrdahl M, Joshi AD, Auer PL, Gaudet MM, Milne RL, Schumacher FR, et al. (2016). Breast cancer risk from modifiable and nonmodifiable risk factors among white women in the United States. JAMA oncology. 2(10): 1295-1302.

Mc Donald JA, Goyal A, Terry MB (2014). Alcohol intake and breast cancer risk: Weighing the overallevidence. Curr Breast Cancer Rep.5(3): 10.

Momenimovahed Z, Salehiniya H (2019), Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer (Dove Med Press). 11: 151-164.

Nurhayati (2015). Faktor-faktor risiko yang berhubungan dengan kejadian kanker payudara di rumah sakit Umum Daerah Kota Padangsidimpuan (Risk factors associated with the incidence of breast cancer in the Padangsidim-puan Regional General Hospital).

Jurnal Kesehatan.

Prabandari (2016). Faktor-faktor yang mempengaruhi kejadian kanker payudara di RSU Dadi Keluarga Purwokerto (Factors that influence the incidence of breast cancer at Dadi Family Hospital in Purwokerto). Jurnal Ilmiah Kebidanan. 7(1): 105-11.

Priyantin C, Ulfiana E, Sumarni S (2013). Faktor risiko yang berpengaruh terhadap kejadian kanker payudara di RSUP Dr. Kariadi Semarang (Risk factors that influence the incidence of breast cancer at Dr. Kariadi Hospital Semarang). Jurnal Kebidanan. 2(5): 9-19.

Rianti E, Tirtawati GA, Novita H (2012). Faktor-faktor yang berhubungan dengan risiko kanker payudara wanita (Factors associated with women's breast cancer risk). Jurnal Health Quality. 3(1): 10-23.

Sun YS, Zhao Z, Yang ZN, Xu F, Lu HJ, Zhu ZY, Shi W, et al (2017). Risk factors and preventions of breast cancer. Int J Biol Sci. 13(11): 1387-1397.


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