Biopsychosocial Analysis of Factors on COVID-19 Screening Awareness of Infertile Couples in Assisted Reproductive Technology

Uki Retno Budihastuti, Abdurahman Laqif, Eriana Melinawati, Teguh Prakosa, Hermawan Udiyanto, Heru Priyanto Priyanto, Darto Darto, Affi Angelia Rantasari, Trisulo Wasyanto, Asih Anggraeni, Agung Sari Wijayanti


Background: The development of screening methods for infertility patients during the Coronavirus-2019 (COVID-19) pandemic provides new challenges in the adaptation of children's want programs in the era of the COVID-19pandemic. Several screening methods have been developed but various factors affect the awareness of couples to want to do COVID-19 screening. This study aimed to analyze biopsychosocial factors associated with awareness of COVID-19 screening in infertile couples.

Subjects and Method: A cross-sectional study conducted at The Sekar Polyclinic of Dr. Moewardi Regional General Hospital during the COVID-19 pandemic. A number of 60 infertile couple of reproductive age who underwent the ART program was selected by random sampling. The dependent variable was awareness for COVID-19 screening. The independent variables were anxiety, knowledge, age, and length of infertility. The data were obtained from medical record and questionnaire and analyzed by a multiple logistic regression.

Results: Anxiety (OR= 26; 95% CI; p<0.001) and above-average knowledge levels (OR=16; 95% CI; p<0.001) affected awareness for COVID-19 screening. While the age and length of infertility do not affect awareness for COVID-19 screening (p >0.05).

Conclusion: Anxiety and above-average knowledge levels affect awareness for COVID-19 screening.

Keywords: biopsychosocial, COVID-19 screening, infertile, assisted reproductive technology.

Correspondence: Uki Retno Budihastuti. Department of Obstetrics and Gynecology, Faculty of Medicine, Uni­ver­sitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 08122656140.

Journal of Maternal and Child Health (2021), 06(05): 539-546


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Alviggi C, Esteves SC, Orvieto R, Conforti A, La Marca A, Fischer R, Ubaldi, F M (2020). COVID-19 and assisted reproductive technology services: Repercussions for patients and proposal for individualized clinical management. Reprod Biol Endocrinol. 18(1): 1–7.

Barra F, La Rosa VL, Vitale SG, Commodari E, Altieri M, Scala C, Ferrero S (2020). Psychological status of infertile patients who had in vitro fertilization treatment interrupted or postponed due to COVID-19 pandemic: a cross-sectional study. J Psychosom Obstet Gynaecol. 0(0): 1–8.

Boivin J, Harrison C, Mathur R, Burns G, Pericleous-Smith A, Gameiro S (2020). Patient experiences of fertility clinic closure during the COVID-19 pandemic: appraisals, coping and emotions. HUM REPROD (Oxford, England). 35(11): 2556–2566.

Chen Y, Pradhan S, Xue S (2020). What are we doing in the dermatology outpatient department amidst the raging of the 2019 novel coronavirus?. J Am Acad Derm. 82(4): 1034.

Choi HI, Ko HJ, Song JE, Park JY, Kim JH (2021). Safety and Effectiveness of an In-Hospital Screening Station for Coronavirus Disease 2019 in Response to the Massive Community Outbreak. Risk Manag Healthc. 14: 1637–1647.

Cullen W, Gulati G, Kelly BD (2020). Mental health in the COVID-19 pandemic. QJM. 113(5): 311–312.

Elston DM (2020). The coronavirus (COVID-19) epidemic and patient safety. J Am Acad Dermatol. 82(4): 819–820.

Esposito V, Rania E, Lico D, Pedri S, Fiorenza A, Strati MF, Venturella R (2020). Influence of COVID-19 pandemic on the psychological status of infertile couples. Eur J Obstet Gynecol. 253: 148–153.

Fineschi, V, Aprile A, Aquila I, Arcangeli M, Asmundo A, Bacci M, Sapino A (2020). Management of the corpse with suspect, probable or confirmed COVID-19 respiratory infection – Italian interim recommendations for personnel potentially exposed to material from corpses, including body fluids, in morgue structures and during autopsy practi. Pathologica. 112(2): 64–77.

Gordon JL, Balsom AA (2020). The psycho-logical impact of fertility treatment suspensions during the COVID-19 pandemic. PLoS ONE. 15(9): 1–13.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Cao B (2020). Clinical features of patients infected with 2019 novel coro-navirus in Wuhan, China. Lancet.

Lawson AK, Mcqueen DB, Pavone ME (2021). Psychological distress and postponed fertility care during the COVID-19 pandemic. J Assist Reprod Genet. 38(2): 333–341.

Papathanasiou A (2020). COVID-19 screening during fertility treatment: how do guidelines compare against each other? J Assist Reprod Genet. 37(8): 1831–1835.

Pedersen SF, Ho YC (2020). SARS-CoV-2: A storm is raging. J Clin Investig. 130-(5): 2202–2205.

Salie M, Roomaney R, Andipatin M, Volks C (2021). Scoping review of the psychosocial aspects of infertility in deve-loping countries: protocol. BMJ Open. 11(5):e044003.

Seifer DB, Petok WD, Agrawal A, Glenn T L, Bayer AH, Wittn BR, Lieman HJ (2021). Psychological experience and coping strategies of patients in the Northeast US delaying care for infertility during the COVID-19 pandemic. Reprod Biol Endocrinol. 19(1): 28.

Stanhiser J (2018). Psychosocial Aspects of Fertility and Assisted Reproductive Technology. Obstet Gynecol Clin North Am. 45(3): 563–574.

Tokgoz VY, Kaya Y, Tekin AB (2020). The level of anxiety in infertile women whose ART cycles are postponed due to the COVID-19 outbreak. Obstet Gynecol. 1–8.

Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC (2020). Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 324(8): 782–793.

Yuen KS, Ye ZW, Fung SY, Chan CP, Jin, DY (2020). SARS‑CoV‑2 and COVID‑19: The most important research questions. Cell Biosci. 1–5.

Zhao C, Bai Y, Wang C, Zhong Y, Lu N, Tian L, Jin R (2021). Risk factors related to the severity of COVID-19 in Wuhan. Int J Med Sci. 18(1): 120–127.


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