The Role of Ferritin Serum Level as Predictor Sepsis Mortality on Children in Dr. Moewardi Hospital of Surakarta

Agus Sucianto, Pudjiastuti Pudjiastuti, Diah Lintang Kawuryan


Background: Sepsis cause death in the worldwide pediatric population. Eestablishing the diagnosis of sepsis in children is challenging because the symptoms are varied and not specific. Serum ferritin is an acute phase protein which can be elevated in sepsis. This study aimed to determine the role of ferritin level as a predictor for sepsis mortality in pediatric patient

Subject and Methods: A cross sectional study was conducted in children aged between 1 months and 18 years old diagnosed with sepsis who were treated at Dr. Moewardi General Hospital, Surakarta from November 2021 to April 2022.  The statistical analysis used SPSS 25 with p<0.05 was considered significant. The cut off point of serum ferritin level was determined with  ROC curve.

Results: Twenty septic children were included in study, of whom 8 children died and 12 children survived. The mean serum ferritin levels of the subjects who survived and died were 925 ng/ml and 1257 ng/ml, respectively. The serum ferritin level wiht the cut off point of 975 ng/ml had sensitivity and specificity of 87.5% and 75% respectively (p=0.006).

Conclusion: Serum ferritin level can be predictor of mortality in children with sepsis.

Keywords: ferritin, mortality in sepsis, children

Correspondence: Agus Sucianto. Department of Pediatrics, Sebelas Maret University/ Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia. Kolonel Sutarto Street No. 132, Surakarta, Indonesia. Email: Mobile: 081227595134.

Journal of Maternal and Child Health (2023), 08(02): 210-216


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