The Effectiveness of Letrozole Adjuvant Therapy - Electro Acupuncture in Reducing the Number of Follicles and Body Weight and Increasing Endometrial Thickness in Women with Polycystic Ovary Syndrome

Todung Antony Wesliaprilius, Uki Retno Budihastuti, Eriana Melinawati, Sri Sulistyowati, Ida Nurwati, Cahyono Hadi


Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Acupuncture can improve menstrual cycle recovery and decrease body mass index (BMI) in women with PCOS. The effect of acupuncture can be enhanced by giving letrozol. Researchers are interested in knowing the comparison between letrozol therapy with letrozol + electroacupuncture on body weight, follicle count, and endometrial thickness in women with polycystic ovary syn­drome. This study aims to determine the diffe­rences in weight loss, follicle number, and endometrial thickness in PCOS patients receiving letrozol treatment compared to letrozol + electroacupuncture.

Subjects and Method: An observational ana­lytic study using a case-control approach and fixed disease sampling technique was carried out at the Gynecology Polyclinic and Sekar Clinic at Dr Moewardi Hospital, Sura­karta. Group 1 consisted of 15 infertile SOPK women who received letrozol and group 2 consisted of 15 infertile SOPK women who received electro­acupuncture + letrozol. Body weight, follicle count, and endometrial thick­ness were measured in both groups. Data were analyzed univariate, bivariate and multivariate using the IBM-SPSS version 22 and STATA version 13 statistical applications.

Results: There was a significant difference in the thickness of the endometrium (p= 0.008), the number of follicles on day 6 (p= 0.039), the number of follicles on day 8 (p= 0.033), the number of follicles on day 10 (p= 0.041), the number of follicles on day 12 (p= 0.041) ) with letrozol therapy with letrozol + electroacupunc­ture. There was no significant difference in body weight between groups

Conclusion: There were significant diffe­ren­ces between the letrozol group compared to the letrozol + electroacupuncture group in endo­metrial thickness and on the number of follicles on days 6, 8, 10, 12 in infertile PCOS women. However, there was no significant difference in body weight between groups.

Keywords: number of follicles, endometrial thickness, PCOS, letrozol, electroacupuncture

Correspondence: Todung Antony Wesliaprilius. Department of Obstetrics and Gynecology, Faculty of Medi­cine, Universitas Sebelas Maret/ Dr. Moewardi hospital, Surakarta. Mobile: 08222181626 Email:

Journal of Maternal and Child Health (2021), 06(02): 219-228

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