The Effectiveness of Letrozole Adjuvant Therapy - Electro Acupuncture in Reducing the Number of Follicles and Body Weight and Increasing Endometrial Thickness in Women with Polycystic Ovary Syndrome
Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Acupuncture can improve menstrual cycle recovery and decrease body mass index (BMI) in women with PCOS. The effect of acupuncture can be enhanced by giving letrozol. Researchers are interested in knowing the comparison between letrozol therapy with letrozol + electroacupuncture on body weight, follicle count, and endometrial thickness in women with polycystic ovary syn
References
Azziz R, Carmina E, Chen ZJ, Dunaif A, Laven, JSE, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ, Yildiz BO (2016). Polycystic ovary syndrome. Nat Rev Dis Primers, 2: 1-18. https://doi.org/10.1038/nrdp.20-16.57.
Badawy A, Aal IA, Abulatta M (2009). Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial. Fertil Steril. 92(3): 849-852. https://doi.org/10.1016/j.fertnstert.2007.02.062.
Chang R, Chung PH, Rosenwaks Z (2002). Role of acupuncture in the treatment of female infertility. Fertil Steril. 78(6): 1149-1153. https://doi.org/10.1016/s00150282(02)043480.
Chen Y, Yang T, Hao C, Zhao J (2018). A retrospective study of letrozole treatment prior to human chorionic gonadotropin in women with polycystic ovary syndrome undergoing in vitro fertilization at risk of ovarian hyperstimulation syndrome. Med Sci Monit Basic Res. 24: 4248-4253. https://dx.doi.org/10.12659%2FMSM.910743.
Cho SH, Lee JS, Thabane L, Lee J (2009). Acupuncture for obesity: a systematic review and meta-analysis. Int J Obes, 33(2):183
Diamond MP, Legro RS, Coutifaris C, et al. (2015). Letrozole, gonadotropin, or clomiphene for unexplained infertility. N Engl J Med, 373(13): 1230-1240. https://doi.org/10.1056/NEJ-Moa1414827.
Franik S, Eltrop SM, Kremer JAM, Kiesel L, Farquhar C (2018). Aromatase inhibi-tors (letrozole) for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 5(5): 1-166. https://doi.org/10.1002/146518-58.cd010287.pub3.
Gao Z, Yu Z, Song ZX, Zhang CR, Wang YS, Wu YF, Zhou B, et al. (2015). Comparative effectiveness of electroacupuncture plus lifestyle modification treatment for patients with simple obesity and overweight: study protocol for a randomized controlled
trial. Trials. 16: 525. https://doi.org/10.1186/s13063-015-1046-x.
Huang ST, Chen APC (2008). Traditional Chinese medicine and infertility.Curr Opin Obstet Gyn, 20(3): 211
Johansson J, Stener-Victorin E (2013). Polycystic ovary syndrome: Effect and mechanism of acupuncture for ovulation induction. Evid Based Complement Altern Med. 1-16. https://doi.org/10.1155/2013/762615.
Karim F, Diley J, Cheung E. 2019. A review of acupuncture in obstetrics and gynaecology. Obstet Gynaecol. 21: 209-14. https://doi.org/10.1111/tog.-12574.
Lee TT, Rausch ME (2012). Polycystic ovarian syndrome: Role of imaging in diagnosis. Radiographics, 32(6): 1643-1657. https://doi.org/10.1148/rg.326125503.
De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petralgia F (2016). Genetic, hormonal, and metabolic aspects of PCOS: An update. Reprod Biol Endocrinol. 14(38): 1-17. https://doi.org/10.1186/s12958-016-0173-x.
Legro R, Brzyski R, Diamond M, Coutifaris C, Schlaff W, Casson P, et al. 2014. Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. N Engl J Med, 371(2): 119-129. https://doi.org/10.1056/nejmoa-1313517.
Li J, Ng E, Stener-Victorin E, Hu Z, Wu W, Lai M, Wu T, Ma H (2016). Comparison of acupuncture pretreatment followed by letrozole versus letrozole alone on live bbirth in anovulatory infertile women with polycystic ovary syndrome: A study protocol for a randomised controlled trial. BMJ Open 6(10): e010955. https://doi.org/10.1136/bmjopen-2015-010955.
Mukherjee G, Khatsgir G, Basu S (2018). Practical guide in infertility. New Delhi: The Health Sciences Publisher.
Nyrop KA, Deal AM, Lee JT, Muss HB, Choi SK, Dixon S, Wheless A, Carey LA (2017). Weight change in postmenopausal breast cancer survivors: Inde-pendent effects of adjuvant tamoxifen and aromatase inhibitors. J Clin Oncol. 34(15): 1-14. https://doi.org/10.1007/s10549-017-4106-y.
Saleem F, Rizvi SW (2017). New therapeutic approaches in obesity and metabolic syndrome associated with polycystic ovary syndrome. Cureus, 9(11): e1844. https://doi.org/10.7759/cure-us.1844.
Stener-Victorin E, Maliqueo M, Soligo M, Protto V, Manni L, Jerlhag E, Kokosar M, et al. (2016). Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture. Obes Sci Pract. 2(4):426-435. https://dx.doi.org/10.1002%2-Fosp4.78.
Sui Y, Zhao HL, Wong VC, Brown N, Li XL, Kwan AKL, Hui HLW, et al. (2012). A systematic review on use of Chinese medicine and acupuncture for treatment of obesity. Obes Rev, 13(5): 409-430. https://doi.org/10.1111/j.1467-789x.2011.00979.x.
Yang W, Yang R, Yang S, Li J, Tu B, Gao C, Wang Y (2018). Infertile polycystic ovary syndrome patients undergoing in vitro fertilization with the gonadotropin-releasing hormoneantagonist protocol: role of hyperandrogenism. Gynecol Endocrinol. 34(8): 715-718. https://doi.org/10.1080/09513590.2018.1431773.
Yin Y, Zhang Y, Zhang H, Jiang D, Guo G (2018). Clinical therapeutic effects of acupuncture combined with Chinese herbal medicine on infertility of polycystic ovary syndrome in the patients with ovulation induction with letrozole. Zhongguo Zhen jiu (Chinese Acupuncture & Moxibustion). 38(1): 27-32. https://doi.org/10.13703/j.02-55-2930.2018.01.006.
Zheng YH, Wang XH, Lai MH, Yao H, Liu H, Ma HX (2013). Effectiveness of abdominal acupuncture for patients with obesitytype polycystic ovary syndrome: A randomized controlled trial. J Altern Complement Med, 19(9): 740-745. https://doi.org/10.10-89/acm.2012.0429.